| 产品编号 | bsm-61302R |
| 英文名称 | FANCD2 Recombinant Rabbit mAb |
| 中文名称 | FANCD2重组兔单抗 |
| 别 名 | FA D2; FA4; FAC D2; FACD 2; FACD; FACD2; FAD; FAD2; FANCD 2; FANCD; FANCD2; Fanconi anemia group D2 protein; FLJ23826; Protein FACD2; Type 4 Fanconi pancytopenia. |
| 抗体来源 | Rabbit |
| 克隆类型 | |
| 克 隆 号 | 17C6 |
| 产品应用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 164 kDa |
| 检测分子量 | 166 |
| 性 状 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human FANCD2: 200-255/1451 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. SWISS: Q9BXW9 Gene ID: 2177 FANCD2是一种在DNA损伤修复过程中起重要作用的蛋白质，其作作用在于通过修补DNA损伤或促进有缺陷细胞自杀来预防癌症，所以低水平的FANCD2会导致DNA损伤，从而诱发癌症。 有学者认为:FANCD2是个重要的抵御癌症蛋白，而香烟会破坏它的制造过程当然还可能包含有其他蛋白，但至少FANCD2是关键的主要蛋白，因为含有非常高水平FANCD2的细胞能够抵御香烟的毒害作用。 & |
| 产品图片 |
25 ug total protein per lane of various lysates (see on figure) probed with FANCD2 monoclonal antibody, unconjugated (bsm-61302R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
