| 产品编号 | bsm-62128R |
| 英文名称 | DISC1 Recombinant Rabbit mAb |
| 中文名称 | DISC1重组兔单抗 |
| 别 名 | C1orf136; DISC1; KIAA0457; RP4-730B13.1; SCZD9. |
| 抗体来源 | Rabbit |
| 克隆类型 | |
| 克 隆 号 | |
| 产品应用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 94 kDa |
| 检测分子量 | 100 |
| 性 状 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human DISC1: 1-120/854 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis.Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus.Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. SWISS: Q9NRI5 Gene ID: 27185 DISC-1基因的变异增加了患精神分裂症的风险。研究人员发现，抑制老鼠的DISC1活性则改变了动物大脑的发育，引起了大脑皮层轻微的变异，而在对精神分裂症病人进行尸检时在其大脑中见到了此变化。研究人员还发现将DISC1与对大脑发育和调节神经传递素水平很重要的分子信号路径联系起来，精神病患者的神经传递素水平往往是不正常的。 新研究显示DISC1蛋白质与一个叫PDE4B的酶相互作用，而影响信号传递分子cAMP的活性。这个信号传递系统过去在其它试验系统中被发现与学习、记忆、以及情绪有关， |
| 产品图片 |
Western blot analysis of (1) HeLa cell lysate; (2) RAW264.7 cell lysate; (3) PC-12 cell lysate. Using DISC1 (bsm-62128R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
