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RabbitAnti-IL17A Rabbit pAb  antibody (bs-1183R)
~~~促销，代码KXJ230206~~~
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说明书： 50ul  100ul  200ul
50ul/1180.00元
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100ul/1980.00元
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200ul/2800.00元
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产品编号 bs-1183R
英文名称 IL17A Rabbit pAb
中文名称 白介素-17抗体
别    名 Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN; IL17_MOUSE.  
Specific References  (33)     |     bs-1183R has been referenced in 33 publications.
111 [IF=24.897] Yuan, Xulei. et al. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. INT J ORAL SCI. 2023 Jan;15(1):1-14  IHC ;  Mouse.  222
111 [IF=8.786] Xiaoyu Guo. et al. Effects of Boric Acid Gel on Vaginal Candida albicans Infections and the Local Immune System in Mice. FRONT IMMUNOL. 2022; 13: 950215  IHC ;  Mouse.  222
111 [IF=7.324] Yongbo Kang. et al. A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway. MSYSTEMS. 2023 Feb 16  IHC ;  Mouse.  222
111 [IF=7] L.H. Frommherz. et al. Secukinumab for the treatment of SAM syndrome associated with desmoglein‐1 deficiency. 2020 Nov 18  IHC ;  Human.  222
111 [IF=6.575] Qingqing Liu. et al. A Synbiotic Ameliorates Con A-Induced Autoimmune Hepatitis in Mice Through Modulation of Gut Microbiota And Immune Imbalance. MOL NUTR FOOD RES. 2023 Jan;:2200428  IF,IHC ;  Mouse.  222
111 [IF=6.575] Prema Robinson. et al. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. CANCERS. 2023 Jan;15(11):2977  IHC ;  Mouse.  222
111 [IF=6.048] Qingqing Liu. et al. Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability. J Nutr Biochem. 2021 Sep;:108863  IHC ;  mouse.  222
111 [IF=5.714] Mingwei Tong. et al. The Trichinella spiralis-derived antigens alleviate HFD-induced obesity and inflammation in mice. INT IMMUNOPHARMACOL. 2023 Apr;117:109924  IHC ;  Mouse.  222
111 [IF=5.396] Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 May;:  IHC ;  Mouse.  222
111 [IF=5.279] Yan Zhang. et al. Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer’s Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis. J Agr Food Chem. 2021;69(47):14204–14214  WB ;  Mouse.  222
111 [IF=5.195] Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626  IHC ;  Mouse.  222
111 [IF=5.195] Huangguan Qin. et al. Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis. J ETHNOPHARMACOL. 2023 Apr;:116542  WB ;  Rat.  222
111 [IF=4.964] Prema Robinson. et al. Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn’s Disease. J CLIN MED. 2022 Jan;11(23):7020  IHC ;  Mouse.  222
111 [IF=4.36] An Wang. et al. Yiqi Jiedu herbal decoction attenuates the 2 Gy 60Co γ ray induced spleen injury by inhibiting apoptosis and modulating the immune balance. J Ethnopharmacol. 2022 Mar;286:114925  IHC ;  Mouse.  222
111 [IF=4.03] Venkatasubramanian, Sambasivan, et al. "Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection." European Journal of Immunology (2015).  IHC-P ;  Mouse.  222
111 [IF=3.887] Yang LIU. et al. Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis. CHIN J NAT MEDICINES. 2023 Apr;21:263  IHC,IF ;  Mouse.  222
111 [IF=3.69] Qingqing Chen. et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021 Mar;267:113542  IHC ;  Rat.  222
111 [IF=3.642] Emin Kaymak. et al. Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. 2021 Aug 15  IHC ;  Rat.  222
111 [IF=3.457] Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151.  IHC ;  Human.  222
111 [IF=3.411] Zhou Yonglong. et al. Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement. Biomed Res Int. 2021;2021:4229491  other ;  Rat.  222
111 [IF=3.298] Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471  IHC ;  Rat.  222
111 [IF=2.61] Wang N et al. CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol Res. 2019 Dec;67(6):486-496.  IHC-P ;  Mouse.  222
111 [IF=2.55] Chen, Baiwen, et al. "Effects of 1, 25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model." International Immunopharmacology 47 (2017): 182-189.  IHC-F ;  Mouse.  222
111 [IF=2.502] Pu J et al. FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063.  WB ;  Mouse.  222
111 [IF=1.922] Zhu C et al. Roseburia intestinalis inhibits interleukin‑17 excretion and promotes regulatory T cells differentiation in colitis.Mol Med Rep. 2018 Jun;17(6):7567-7574.  IHC-P ;  Mouse.  222
111 [IF=1.834] Emin Kaymak. et al. Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. BIOTECH HISTOCHEM. 2022 Aug 22  IHC ;  Mouse.  222
111 [IF=1.703] Zhao Jian. et al. The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats. NEUROREPORT. 2022 Aug;33(12):534-542  IHC, WB ;  Rat.  222
111 [IF=1.69] Liao, Yanxi, et al. "Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway." Molecular Medicine Reports.  WB ;  Rat.  222
111 [IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.  WB ;  Mouse.  222
111 [IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.  222
研究领域 肿瘤  细胞生物  免疫学  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Mouse, Rat, 
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 15 kDa
检测分子量 15-17
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-17: 85-150/150 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]

Function:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Restricted to a subset of activated T-cells.

Post-translational modifications:
Found both in glycosylated and nonglycosylated forms.

Similarity:
Belongs to the IL-17 family.

SWISS:
Q62386

Gene ID:
16171

Database links:

Entrez Gene: 3605 Human

Entrez Gene: 16171 Mouse

Entrez Gene: 301289 Rat

Omim: 603149 Human

SwissProt: Q16552 Human

SwissProt: Q62386 Mouse

SwissProt: Q61453 Rat

Unigene: 41724 Human

Unigene: 5419 Mouse

Unigene: 218513 Rat




白细胞介素17（IL-17A）是一种来源于活化T淋巴细胞的细胞因子,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性细胞因子和造血细胞因子参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。
产品图片
Sample: Lane 1: Rat Lymph node tissue lysates Lane 2: Mouse Lymph node tissue lysates Lane 3: Rat Thymus tissue lysates Primary: Anti-IL17A (bs-1183R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 15 kD Observed band size: 22 kD
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