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RabbitAnti-IL18 Rabbit pAb  antibody (bs-0529R)
~~~促销，代码KXJ230206~~~
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说明书： 50ul  100ul  200ul
50ul/1180.00元
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100ul/1980.00元
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200ul/2800.00元
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产品编号 bs-0529R
英文名称 IL18 Rabbit pAb
中文名称 白细胞介素-18/干扰素γ诱导因子抗体
别    名 Interleukin-18; interferon gamma-inducing factor IGIF; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; Iboctadekin; IFN gamma inducing factor; IGIF; IL 1 gamma; IL 18; IL-18; IL 1g; IL1 gamma; IL18 protein; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin18; MGC12320; IL18_MOUSE.  
Specific References  (26)     |     bs-0529R has been referenced in 26 publications.
111 [IF=16.907] Yunxiang Sun. et al. Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta. Nano Today. 2021 Jun;38:101125  WB ;  Mouse.  222
111 [IF=9.811] Nicholas Andrikopoulos. et al. Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles. Chem Mater. 2021;XXXX(XXX):XXX-XXX  WB ;  Mouse.  222
111 [IF=9.043] Jiayu Yu. et al. Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites. MICROBIOL SPECTR. 2023 Jan 31  WB ;  Mouse.  222
111 [IF=8.025] Lihui Ni. et al. The combination of insulin and linezolid ameliorates Staphylococcus aureus pneumonia in individuals with diabetes via the TLR2/MAPKs/NLRP3 pathway. INT J BIOL MACROMOL. 2023 Jul;242:124750  WB ;  Mouse.  222
111 [IF=7.129] Ruxue Jia. et al. PM2.5 induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway. ECOTOX ENVIRON SAFE. 2023 Apr;254:114699  WB ;  Mouse.  222
111 [IF=6.291] Shaofeng Wu. et al. The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks. Ecotox Environ Safe. 2021 Dec;228:112965  WB ;  Duck.  222
111 [IF=5.793] Yuan Changet al. NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury. J Neuroinflammation . 2020 Jul 23;17(1):219.  WB ;  rat.  222
111 [IF=5.62] Weijian Fan. et al. RGD1564534 represses NLRP3 inflammasome activity in cerebral injury following ischemia-reperfusion by impairing miR-101a-3p-mediated Dusp1 inhibition. EXP NEUROL. 2022 Nov;:114266  WB ;  Rat.  222
111 [IF=4.691] Xiaoli Liu. et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes. Exp Neurol. 2021 Mar;:113700  WB ;  Rat.  222
111 [IF=4.527] Gao M et al. Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo (a) pyrene and lipopolysaccharide? Ecotoxicol Environ Saf. 2019 Sep 24;185:109687.  IHC ;  Mouse.  222
111 [IF=3.943] Mengli Cui et al. NLRP3 inflammasome is involved in nerve recovery after sciatic nerve injury. Int Immunopharmacol. 2020 Jul;84:106492.  WB ;  Mouse.  222
111 [IF=3.921] Meiyun Cai. et al. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway. Neurochem Int. 2021 Nov;:105221  WB ;  Rat.  222
111 [IF=3.869] Kong Dejun. et al. IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury. Stem Cells Int. 2020;2020:8883636  WB ;  Rat.  222
111 [IF=3.758] Lei Xianghong. et al. Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells. Mediat Inflamm. 2020;2020:3934769  WB ;  Rat.  222
111 [IF=3.553] Wu Z et al. Pyroptosis engagement and bladder urothelial cells derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after UPEC infection. Am J Physiol Cell Physiol. 2019 Jun 26.  WB ;  Mouse.  222
111 [IF=3.188] Bian X et al. Periostin contributes to renal and cardiac dysfunction in rats with chronic kidney disease: reduction of PPARα.Biochimie. 2019 May;160:172-182.  WB ;  Rat.  222
111 [IF=3.105] Xiao-ling Zhang. et al. Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission. Neurotoxicology. 2021 May;84:1  WB ;  Rat.  222
111 [IF=3.063] Liu T et al. MicroRNA-193b-3p regulates hepatocyte apoptosis in selenium-deficient broilers by targeting MAML1.J Inorg Biochem. 2018 Sep;186:235-245.  WB ;  broiler chick.  222
111 [IF=2.649] Shao H et al. Glyburide attenuates ozone‐induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome. Environ Toxicol. 2020 Mar 13.  IHC ;  mouse.  222
111 [IF=2.649] Duan S et al. NLRP3 inflammasome activation is associated with PM2. 5‐induced cardiac functional and pathological injury in mice. Environ Toxicol. 2019 Jul 16.  IHC ;  Mouse.  222
111 [IF=2.615] Wei Yu. et al. Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner. Cardiovasc Diagn The. 2020 Aug; 10(4): 752–769  WB ;  Mouse.  222
111 [IF=2.479] Wangyu Wu. et al. Cholecalciferol pretreatment ameliorates ischemia/reperfusion-induced acute kidney injury through inhibiting ROS production, NF-κB pathway and pyroptosis. Acta Histochem. 2022 May;124:151875  IF ;  Mouse.  222
111 [IF=1.034] Yuyang Li. et al. Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis. J Dent Sci. 2021 Jan;:  IHC ;  Human.  222
111 [IF=0.737] Yang S. Y.. et al. Exosomes Derived from Endothelial Cells Inhibit Neointimal Hyperplasia Induced by Carotid Artery Injury in Rats via ROS-NLRP3 Inflammasome Pathway. B EXP BIOL MED+. 2023 May;:1-6  WB ;  Rat.  222
111 [IF=0.439] Chen JW et al. Zhihuang Tongfeng decoction ameliorates gouty arthritis via inhibition of NLRP3 inflammasome in rats. Tropical Journal of Pharmaceutical Research December 2019; 18 (12): 2577-2582.  WB ;  Rat.  222
111 [IF=0] Kong D et al. IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury. Research Square. 17 February 2020.  WB ;  Rat.  222
研究领域 免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human, 
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 22 kDa
检测分子量
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 Recombinant human IL-18 protein: 37-193/193 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 IL18 (IFN-gamma-inducing factor, IGIF) is a novel pro-inflammatory cytokine that augments natural killer (NK) activity in spleen cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
IL18 also has other biological properties such as stimulation of Fas ligand expression, and induction of CC and CXC chemokines. IL18 increases production of competent HIV. IL18 is related to the IL1 family. One of the IL18 receptor chains is the IL1 receptor-related protein, a member of the IL 1R family. Like IL1 , IL18 is first synthesized as a leaderless precursor requiring the IL1 converting enzyme (ICE) for cleavage into an active molecule. IL18 may play a role in tissue injury in inflammatory reactions.

Function:
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular Location:
Secreted.

Similarity:
Belongs to the IL-1 family.

SWISS:
Q14116

Gene ID:
3606

Database links:


Entrez Gene: 3606 Human

Entrez Gene: 16173 Mouse

Omim: 600953 Human

SwissProt: Q14116 Human

SwissProt: P70380 Mouse

Unigene: 83077 Human

Unigene: 1410 Mouse




IL-18是巨噬细胞分泌的一个重要因子，它具有多种免疫功能，能诱导产生ＩＦＮγ，无论在病毒感染早期或特异性细胞免疫应答效应阶段都会出现，因此IL-18主要参与免疫应答及炎性细胞浸润的改变。Interleukin-18 又称inteferon-gamma inducing factor(IGIF)，在辅助T细胞的应答反应中起重要作用。IL-18和IL-1一起，既参与先天免疫，又是后天免疫的构成因素。
产品图片
25 ug total protein per lane of various lysates (see on figure) probed with IL-18 polyclonal antibody, unconjugated (bs-0529R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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