产品编号 | bs-1080R |
英文名称 | SOD2 Rabbit pAb |
中文名称 | 超氧化物歧化酶2抗体 |
别 名 | IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN. |
![]() |
Specific References (19) | bs-1080R has been referenced in 19 publications.
|
研究领域 | 神经生物学 细胞凋亡 激酶和磷酸酶 线粒体 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
克 隆 号 | |
交叉反应 | Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理论分子量 | 22 kDa |
检测分子量 | |
细胞定位 | 细胞浆 线粒体 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human SOD2: 41-78/222 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
产品介绍 |
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Subunit: Homotetramer. Subcellular Location: Mitochondrion matrix. Post-translational modifications: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. DISEASE: Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the iron/manganese superoxide dismutase family. SWISS: P04179 Gene ID: 6648 Database links: Entrez Gene: 374042 Chicken Entrez Gene: 6648 Human Entrez Gene: 20656 Mouse Omim: 147460 Human SwissProt: P04179 Human SwissProt: P09671 Mouse SwissProt: P41982 Rabbit Unigene: 487046 Human Unigene: 290876 Mouse Unigene: 10488 Rat SOD2是清除线粒体氧自由基的最主要的酶类,SOD2参与促进细胞分化和肿瘤发生。SOD2的表达缺乏与血管病变、新生儿致死、神经退行性病变有关联。SOD2过度表达与抵御细胞氧化损伤有关。 超氧化物歧化酶又称(Superoxide dismutase,简称SOD)是参与机体抗氧化(ROS,反应性氧离子reactive oxygen species)防御机制和抵御细胞氧化损伤最重要的酶类之一, 广泛存在于需氧生物、耐氧生物及某些厌氧微生物中,目前已知的SOD 主要分为三类,即胞质中Cu/Zn-SOD(即SOD1)、线粒体中的Mn-SOD(即SOD2)和ec-SOD(即SOD3)。 |
产品图片 | |
1、抗体溶解方法 | |
2、抗体修复方式 | |
3、常用试剂的配制 | |
4、免疫组化操作步骤 | |
5、免疫组化问题解答 | |
6、Western Blotting 操作步骤 | |
7、Western Blotting 问题解答 | |
8、关于肽链的设计 | |
9、多肽的溶解与保存 | |
10、酶标抗体效价测定程序 | |