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RabbitAnti-FASN Rabbit pAb antibody (bs-1498R)
~~~促销，代码KXJ230206~~~

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产品编号	bs-1498R
英文名称	FASN Rabbit pAb
中文名称	脂肪酸合成酶抗体
别名	fatty acid synthase; FASN; FAS; FA Synthase 1; MGC14367; MGC15706; OA-519; Fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; Enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase; FAS_MOUSE.
	Specific References (7) \| bs-1498R has been referenced in 7 publications. 111 [IF=5.168] Yu et al. LncRNA as ceRNAs may be involved in lactation process. (2017) Oncotarget. 8:98014-98028 IF(IHC-P) ; Goat. 222 PubMed:29228670 111 [IF=4.192] Zhi Chenet al. Circ09863 Regulates Unsaturated Fatty Acid Metabolism by Adsorbing miR-27a-3p in Bovine Mammary Epithelial Cells. J Agric Food Chem . 2020 Aug 12;68(32):8589-8601. WB ; cow. 222 PubMed:32689797 111 [IF=3.67] Zhao Z et al. Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK/Nrf2 pathway. Appl Microbiol Biotechnol. 2019 May 21. WB ; Mouse. 222 PubMed:31115630 111 [IF=3.241] Sun W et al. Baicalein reduced hepatic fat accumulation by activating AMPK in oleic acid-induced HepG2 cells and high-fat diet-induced non-insulin resistant mice. Food Funct. 2020 Jan 7. WB ; Mouse. 222 PubMed:31909773 111 [IF=3.23] Li M, Ye T, Wang X-X, Li X, Qiang O, Yu T, et al. (2016) Effect of Octreotide on Hepatic Steatosis in Diet-Induced Obesity in Rats. PLoS ONE 11(3): e0152085 IHC-P ; Rat. 222 PubMed:27002331 111 [IF=3.23] Chen Z, Luo J, Ma L, Wang H, Cao W, Xu H, et al. (2015) MiR130b-Regulation of PPARγ Coactivator- 1α Suppresses Fat Metabolism in Goat Mammary Epithelial Cells. PLoS ONE 10(11): e0142809 WB ; Goat. 222 PubMed:26579707 111 [IF=1.65] Zhu, J. J., et al. "Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland." Animal (2014): 1-10. other ; PubMed:24909980
研究领域	肿瘤心血管免疫学神经生物学信号转导激酶和磷酸酶合成与降解
抗体来源	Rabbit
克隆类型	Polyclonal
克隆号
交叉反应	Human, Rat, (predicted: Mouse, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	272 kDa
检测分子量
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from humanFASN: 1451-1550/2411
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	FASN (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis. FAS is a target for SREBP and is upregulated by LXR activation; it is also one of the accepted markers for insulin resistance, SREBP and LXR activation. Function: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. Subunit: Homodimer which is arranged in a head to tail fashion. Subcellular Location: Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Tissue Specificity: Ubiquitous. Prominent expression in brain, lung, and liver. Similarity: Contains 1 acyl carrier domain. SWISS: P49327 Gene ID: 2194 Database links: Entrez Gene: 2194 Human Entrez Gene: 14104 Mouse Entrez Gene: 50671 Rat Entrez Gene: 281152 Cow Omim: 600212 Human SwissProt: P12276 Chicken SwissProt: Q71SP7 Cow SwissProt: P49327 Human SwissProt: P19096 Mouse SwissProt: P12785 Rat Unigene: 8951 Chicken Unigene: 30099 Cow Unigene: 83190 Human Unigene: 236443 Mouse Unigene: 9486 Rat 合成与降解（Synthesis and Degradation）脂肪酸合成酶fatty acid synthase是一种新的肿瘤标志物,高表达常提示肿瘤的预后不良.
产品图片	Sample: Lane 1: Human HeLa cell lysates Lane 2: Human HepG2 cell lysates Primary: Anti-FASN (bs-1498R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 272 kDa Observed band size: 250 kDa

	免疫组化常用试剂
	免疫印迹常用试剂
	各种标记二抗

	1、抗体溶解方法
	2、抗体修复方式
	3、常用试剂的配制
	4、免疫组化操作步骤
	5、免疫组化问题解答
	6、Western Blotting 操作步骤
	7、Western Blotting 问题解答
	8、关于肽链的设计
	9、多肽的溶解与保存
	10、酶标抗体效价测定程序

	Alexa Fluor 350 标记
	Alexa Fluor 488 标记
	Alexa Fluor 555 标记
	Alexa Fluor 594 标记
	Alexa Fluor 647 标记
	AP 标记
	APC 标记
	Biotin 标记
	Cy3 标记
	Cy5 标记
	Cy5.5 标记
	Cy7 标记
	FITC 标记
	Gold 标记
	HRP 标记
	PE 标记
	PE-Cy3 标记
	PE-CY5 标记
	PE-CY5.5 标记
	PE-CY7 标记
	RBITC 标记