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RabbitAnti-GLP-1R Rabbit pAb  antibody (bs-1559R)
~~~促销，代码KXJ230206~~~
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说明书： 50ul  100ul  200ul
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产品编号 bs-1559R
英文名称 GLP-1R Rabbit pAb
中文名称 胰高血糖素样肽-1受体/GLP-1受体抗体
别    名 Glucagon like peptide-1 receptor; GLP 1 R; GLP 1 receptor; GLP 1R; Glp1r; GLP; glp1r; Glucagon like peptide 1 receptor; RATGL1RCP; Glip; MGC138331; GLP-1-R; GLP1R_HUMAN; Glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R; Precursor.  
Specific References  (16)     |     bs-1559R has been referenced in 16 publications.
111 [IF=5.71] Zhou, Hao, et al. "Exendin-4 protects ADMSCs from apoptosis induced by Hydrogen peroxide through PI3K/Akt-Sfrp2 pathways." Free Radical Biology and Medicine (2014).  Rat.  222
111 [IF=5.7] Shan Y et al. The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke. J Neuroinflammation. 2019 Nov 28;16(1):242.  IHF ;  Rat.  222
111 [IF=5.682] Haoqiang Zhang. et al. Glucagon-like peptide-1 attenuated carboxymethyl lysine induced neuronal apoptosis via peroxisome proliferation activated receptor-γ. Aging-Us. 2021 Jul 31; 13(14): 19013–19027  WB ;  Rat.  222
111 [IF=5.64] Yuping Chen. et al. The Herb Pair Radix Rehmanniae and Cornus Officinalis Attenuated Testicular Damage in Mice With Diabetes Mellitus Through Butyric Acid/Glucagon-Like Peptide-1/Glucagon-Like Peptide-1 Receptor Pathway Mediated by Gut Microbiota. Front Microbiol. 2022 Feb 22;13:831881  IF,WB ;  Mouse.  222
111 [IF=5.037] Zhan-zhao Liu. et al. Glucagon-like peptide-1 receptor activation by liraglutide promotes breast cancer through NOX4/ROS/VEGF pathway. Life Sci. 2022 Apr;294:120370  WB ;  Human.  222
111 [IF=4.013] Hongzeng Li. et al. Eugenol alleviated nonalcoholic fatty liver disease in rat via a gut-brain-liver axis involving glucagon-like Peptide-1. ARCH BIOCHEM BIOPHYS. 2022 May;:109269  WB,IF ;  Rat.  222
111 [IF=3.841] Qiaoji Tian. et al. Glucagon-Like Peptide-1 Receptor Mediates the Improvement in Glycolipid Metabolism Disorder via AKT and AMPK Signalling Pathways in L02 Cells with Insulin Resistance. J MOL STRUCT. 2022 Oct;:134328  IHC ;  Human.  222
111 [IF=3.647] Melek T et al. Ileal interposition improves metabolic syndrome parameters in a rat model of metabolic syndrome induced by monosodium glutamateLife Sci.2020 Dec 9;266:118846.  WB ;  Rat.  222
111 [IF=3.469] Shuangli Yang. et al. Glucagon-like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of rapamycin pathway. Am J Physiol-Endoc M. 2020 Nov;319(6):E1019-E1030  WB,IF ;  Rat.  222
111 [IF=3.288] Kanda et al. Expression of the glucagon-like peptide-1 receptor and its role in regulating autophagy in endometrial cancer. (2018) BMC.Cancer. 18:657  WB ;  Human.  222
111 [IF=3.124] Wu Li. et al. GLP1R inhibits the progression of endometrial carcinoma through activation of cAMP/PKA pathway. J CLIN LAB ANAL. 2022 Aug;:e24604  WB ;  Human.  222
111 [IF=3.06] Nagai, Takuo, et al. "Linagliptin Ameliorates Methylglyoxal-Induced Peritoneal Fibrosis in Mice." PLOS ONE 11.8 (2016): e0160993.  WB, IHC-P ;  Mouse.  222
111 [IF=2.559] Wen Y et al. Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy. Biochem Biophys Res Commun. 2019 Mar 26;511(1):79-86.  IP,WB&IHC ;  Rat&Human.  222
111 [IF=2.395] Kim SJ et al. DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction.BMC Nephrol. 2019 Mar 1;20(1):75.  WB ;  Rat.  222
111 [IF=2.276] Liu Jinlei. et al. Emodin Attenuated the Kidney Damage of High-Fat-Diet Mice via the Upregulation of Glucagon-Like Peptide-1 Receptor. Biomed Res Int. 2021;2021:6662704  WB ;  Mouse.  222
111 [IF=1.448] Bułdak Ł et al. The impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions. Exp Ther Med. 2019 Apr; 17(4): 2861–2869.  WB ;  Human.  222
研究领域 免疫学  生长因子和激素  糖尿病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,  (predicted: Dog, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 51 kDa
检测分子量
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat GLP-1R: 101-200/463 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 GLP1R is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.It has been suggested that this protein influences the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. GLP1R is believed to be expressed in human pancreas,lung, brain, stomach, kidney and heart. ESTs have been isolated from skin and kidney libraries.

Function:
This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit:
May form homodimers and heterodimers with GIPR.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Post-translational modifications:
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

Similarity:
Belongs to the G-protein coupled receptor 2 family.

SWISS:
P32301

Gene ID:
25051

Database links:

Entrez Gene: 2740 Human

Entrez Gene: 14652 Mouse

Entrez Gene: 25051 Rat

Omim: 138032 Human

SwissProt: P43220 Human

SwissProt: O35659 Mouse

SwissProt: P32301 Rat

Unigene: 389103 Human

Unigene: 390969 Mouse

Unigene: 11408 Rat



GLP-1R是GLP-1在体内作用的主要靶点,它是一个7次跨膜的G蛋白偶联受体,以cAMP为主要第二信使。GLP-1与GLP-1R结合过程是一个两结构域相互作用的过程,都与胰岛素分泌和糖代谢调节密切相关。
产品图片
Sample: Lane 1: Mouse Pancreas tissue lysates Lane 2: Mouse Liver tissue lysates( negative control) Primary: Anti-GLP-1R (bs-1559R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band size: 55 kDa
Paraformaldehyde-fixed, paraffin embedded Human Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Rat Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with GLP-1R Polyclonal Antibody, Unconjugated (bs-1559R) at 1:800 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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