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RabbitAnti-lamin B1 Rabbit pAb  antibody (bs-1840R)
~~~促销,代码KXJ230206~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-1840R
英文名称 lamin B1 Rabbit pAb
中文名称 核纤层蛋白B(细胞核膜标志物)抗体
别    名 LMNB1_HUMAN; Lamin-B1; LMNB1; LMN2; LMNB; LMN; ADLD; MCPH26;  
Specific References  (22)     |     bs-1840R has been referenced in 22 publications.
111 [IF=14.224] Biqi Han. et al. Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails. J HAZARD MATER. 2023 Jan;442:130082  WB ;  Quail.  222
111 [IF=10.679] Pan J et al. lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling. Mol Cancer. 2020 Jan 15;19(1):9.  WB ;  Human.  222
111 [IF=9.988] Jia-Xin Wang. et al. Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis. ENVIRON POLLUT. 2023 Jan;317:120717  WB ;  Mouse.  222
111 [IF=9.078] Chun Dai. et al. A novel UV-curable extravascular stent to prevent restenosis of venous grafts. Compos Part B-Eng. 2021 Nov;225:109260  WB ;  Rat.  222
111 [IF=5.999] Jinsheng Li. et al. Micro/nano-topography Promotes Osteogenic Differentiation of Bone Marrow Stem Cells by Regulating Periostin Expression. COLLOID SURFACE B. 2022 Jul;:112700  WB ;  Rat.  222
111 [IF=5.235] Pu, Luya. et al. Laminar shear stress alleviates monocyte adhesion and atherosclerosis development via miR-29b-3p/CX3CL1 axis regulation. J CELL SCI. 2022 Jul;135(14):  WB ;  Human.  222
111 [IF=5.168] Ruonan Wang. et al. The role of mitochondrial dynamics imbalance in hexavalent chromium-induced apoptosis and autophagy in rat testis. CHEM-BIOL INTERACT. 2023 Apr;374:110424  WB ;  Rat.  222
111 [IF=5.085] Feng Yanzhong. et al. Ulva prolifera Extract Alleviates Intestinal Oxidative Stress via Nrf2 Signaling in Weaned Piglets Challenged With Hydrogen Peroxide. Front Immunol. 2020 Oct;11:2840  WB ;  Pig.  222
111 [IF=4.868] Wang Z et al. Aronia melanocarpa Prevents Alcohol-Induced Chronic Liver Injury via Regulation of Nrf2 Signaling in C57BL/6 Mice. Oxid Med Cell Longev. 2020 Jan 8;2020:4054520.  WB ;  Mouse.  222
111 [IF=4.784] Wan B et al. Porcine FcγRIIb mediated PRRSV ADE infection through inhibiting IFN-β by cytoplasmic inhibitory signal transduction. Int J Biol Macromol. 2019 Jul 5;138:198-206.  WB ;  Monkey.  222
111 [IF=4.556] Gi Ho Lee. et al. Impressic Acid Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Activating the AMPK/GSK3β/Nrf2 Axis in RAW264.7 Macrophages. Int J Mol Sci. 2021 Jan;22(2):762  
111 [IF=4.268] Xiping Yang. et al. The piperine derivative HJ105 inhibits Aβ1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis. Phytomedicine. 2021 Apr;:153571  WB ;  Rat.  222
111 [IF=4.171]   WB ;  mouse.  222
111 [IF=4.171] Zhao Y et al. Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells. Food Funct. 2020 Jul 22;11(7):5815-5826.  WB ;  Mouse.  222
111 [IF=4.171] Yuan Gao. et al. Lactobacillus plantarum Y44 alleviates oxidative stress by regulating gut microbiota and colonic barrier function in Balb/C mice with subcutaneous D-galactose injection. Food Funct. 2021 Jan;12(1):373-386  WB ;  Mouse.  222
111 [IF=3.845] Jiang Z et al. The Essential Oils and Eucalyptol From Artemisia vulgaris L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2-Keap1 and Enhancing APAP Clearance Through Non-Toxic Metabolic Pathway. Front Pharmacol. 2019 Jul 25;10:782.  WB ;  Mouse&Rat.  222
111 [IF=3.69] Xiaoyan Xia. et al. Ameliorative effect of white tea from 50-year-old tree of Camellia sinensis L. (Theaceae) on kidney damage in diabetic mice via SIRT1/AMPK pathway. J Ethnopharmacol. 2021 May;272:113919  WB ;  Mouse.  222
111 [IF=3.367] Lijin Guo. et al. Whole Transcriptome Analysis of Chicken Bursa Reveals Candidate Gene That Enhances the Host’s Immune Response to Coccidiosis. Front Physiol. 2020; 11: 573676  WB ;  Chicken.  222
111 [IF=3.204] Chi Li. et al. Schisantherin D from Schisandra chinensis (Turcz.) Baill. exhibits anti-liver fibrosis capacity via modulating ETBR involved signaling, an in vitro and in vivo study. FITOTERAPIA. 2022 Oct;162:105290  WB ;  Mouse, Human.  222
111 [IF=3.06] Wang, Huihui. et al. Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model. 2021 Sep 20  WB ;  Rat.  222
111 [IF=2.952] Xiao-Lin Huang. et al. Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL‑mediated NF‑κB and JNK and their downstream signalling pathways. Mol Med Rep. 2022 Feb;25(2):1-12  WB ;  Mouse.  222
111 [IF=2.742] Wang Mengya. et al. Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway. MOL BIOL REP. 2023 Mar;:1-11  WB ;  Rat.  222
研究领域 细胞生物  染色质和核信号  信号转导  细胞凋亡  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human, Rat,  (predicted: Mouse, Pig, Cow, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 64 kDa
检测分子量
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lamin B: 361-460/586 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010].

Function:
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Subunit:
Homodimer. Interacts with lamin-associated polypeptides IA, IB and 2.

Subcellular Location:
Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.

Post-translational modifications:
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

DISEASE:
Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P20700

Gene ID:
4001

Database links:

Entrez Gene: 396223 Chicken

Entrez Gene: 4001 Human

Entrez Gene: 16906 Mouse

Entrez Gene: 116685 Rat

Omim: 150340 Human

SwissProt: P14731 Chicken

SwissProt: P20700 Human

SwissProt: P14733 Mouse

SwissProt: P70615 Rat

Unigene: 89497 Human

Unigene: 4105 Mouse

Unigene: 11362 Rat



核膜标志物(Nuclear Envelope Marker)
核纤层蛋白(Lamin) 是紧贴核内膜的一层厚度为20~50nm的纤维蛋白层或纤维网络。核纤层与细胞质骨架、核骨架连成一个整体,一般认为核纤层将核被膜和染色质提供了结构支架。有学者研究认为:lamin蛋白与细胞凋亡及衰老有关联,它包括:核纤层蛋白A、核纤层蛋白B、核纤层蛋白C几个不同亚型的蛋白。
产品图片
25 ug total protein per lane of various lysates (see on figure) probed with lamin B1 polyclonal antibody, unconjugated (bs-1840R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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