| 产品编号 | bs-2621R |
| 英文名称 | IL21 Rabbit pAb |
| 中文名称 | 白介素21抗体 |
| 别 名 | CVID11; IL-21; Za11; IL21_BOVIN; IL21; IL21_HUMAN; IL21_MOUSE; |
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Specific References (3) | bs-2621R has been referenced in 3 publications.
111
[IF=3.06] Guan, Li-juan, et al. "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." Cytokine 72.2 (2015): 160-165. IHC-P ; Human. 222
111
[IF=1.26] Gong, Qiaoqiao, et al. "Increased levels of CCR7 (lo) PD‑1 (hi) CXCR5+ CD4+ T cells, and associated factors Bcl‑6, CXCR5, IL‑21 and IL‑6 contribute to repeated implantation failure." Experimental and Therapeutic Medicine 14.6 (2017): 5931-5941. IHC-P ; Human. 222
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[IF=1.26] Ma et al. Effect of follicular helper T cells on the pathogenesis of asthma. (2017) Exp.Ther.Me. 14:967-972 IHC-P ; Mouse. 222
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| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 18 kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-21: 65-155/155 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Subcellular Location: Secreted. Tissue Specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Similarity: Belongs to the IL-15/IL-21 family. SWISS: Q9HBE4 Gene ID: 59067 Database links: Entrez Gene: 59067 Human Entrez Gene: 60505 Mouse Omim: 605384 Human SwissProt: Q9HBE4 Human SwissProt: Q9ES17 Mouse Unigene: 567559 Human Unigene: 157689 Mouse 白介素21是多效免疫调节活性的细胞因子,与其受体结合后可以调节并促进B细胞、T细胞、NK细胞的增殖、分化并提高NK细胞杀伤活性。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
