| 产品编号 | bs-2183R |
| 英文名称 | CLDN11 Rabbit pAb |
| 中文名称 | 少突胶质细胞跨膜蛋白抗体 |
| 别 名 | CLD11_HUMAN; Oligodendrocyte Specific Protein; Oligodendrocyte transmembrane protein; Claudin 11; claudin11; claudin-11; CLDN 11; OSP; OTM. |
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Specific References (5) | bs-2183R has been referenced in 5 publications.
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[IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017). IHC-P ; Mouse. 222
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[IF=4.067] Wang X et al. LRRC75A antisense lncRNA1 knockout attenuates inflammatory responses of bovine mammary epithelial cells. International Journal of Biological Sciences. 2020; 16(2): 251-263. WB&ICF ; Bovine. 222
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[IF=2.9] Zhang, Jianhai, et al. "Sodium fluoride and sulfur dioxide affected male reproduction by disturbing blood-testis barrier in mice." Food and Chemical Toxicology (2016). WB ; Mouse. 222
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[IF=2.8] Zhai J et al. An increase of estrogen receptor α protein level regulates BDE-209-mediated blood-testis barrier disruption during spermatogenesis in F1 mice. (2018) Environ Sci Pollut Res Int. WB,IHF&ICF ; Mouse. 222
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[IF=2.118] Li X et al. Overexpression of lncRNA H19 changes basic characteristics and affects immune response of bovine mammary epithelial cells. PeerJ. 2019 Apr 5;7:e6715. WB ; Bovine. 222
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| 研究领域 | 细胞生物 神经生物学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 22 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin-11: 101-218/218 <Cytoplasmic> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. Subunit: Interacts with tetraspanin-3/TSPAN3. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the claudin family. SWISS: O75508 Gene ID: 5010 Database links: Entrez Gene: 5010 Human Entrez Gene: 18417 Mouse Omim: 601326 Human SwissProt: O75508 Human SwissProt: Q60771 Mouse Unigene: 31595 Human Unigene: 4425 Mouse Unigene: 8282 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
