| 产品编号 | bs-2888R |
| 英文名称 | TRPM2 Rabbit pAb |
| 中文名称 | 瞬时受体电位离子通道蛋白/M亚家族抗体 |
| 别 名 | EREG 1; EREG1; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTRPC2; NUDT9H; NUDT9L1; putative Ca2+channel protein; transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; TRPC 7; TRPC7. |
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Specific References (2) | bs-2888R has been referenced in 2 publications.
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[IF=7.525] Li, Xiangji. et al. The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels. CELL COMMUN SIGNAL. 2022 Dec;20(1):1-15 IHC, WB ; Human. 222
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[IF=4.081] Yıldızhan, Kenan. et al. Involvement of TRPM2 Channel on Doxorubicin-Induced Experimental Cardiotoxicity Model: Protective Role of Selenium. BIOL TRACE ELEM RES. 2022 Aug;:1-12 IHC ; Rat. 222
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| 研究领域 | 免疫学 神经生物学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human, (predicted: Mouse, Rat, Horse, ) |
| 产品应用 | ELISA=1:2000-5000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 165 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRPM2: 951-1050/1503 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. Contains 1 nudix hydrolase domain. SWISS: O94759 Gene ID: 7226 Database links: Entrez Gene: 7226 Human Entrez Gene: 28240 Mouse Omim: 603749 Human SwissProt: O94759 Human SwissProt: Q5KTC0 Mouse SwissProt: Q91YD4 Mouse Unigene: 369759 Human Unigene: 276762 Mouse Unigene: 214495 Rat TRPM2 属于瞬时受体电位离子通道蛋白家族的M亚家族，是一种非选择性的阳离子通道蛋白, 是离子通道蛋白参与了单核细胞的氧化应激应答反应，与老年性痴呆等神经退行疾病的发生与发展有着十分密切的联系. |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
