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RabbitAnti-CYP7A1 Rabbit pAb  antibody (bs-2399R)
~~~促销，代码KXJ230206~~~
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说明书： 50ul  100ul  200ul
50ul/1180.00元
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产品编号 bs-2399R
英文名称 CYP7A1 Rabbit pAb
中文名称 细胞色素P450 7A1抗体/胆固醇7a羟化酶抗体
别    名 Cholesterol 7 alpha hydroxylase; Cholesterol 7 alpha monooxygenase; cholesterol 7 alpha-monooxygenase; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; CP7A; CYP 7; CYP7; CYPVII; Cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; Cytochrome P450, subfamily VIIA(cholesterol 7 alpha monooxygenase); CP7A1_HUMAN.  
Specific References  (19)     |     bs-2399R has been referenced in 19 publications.
111 [IF=7.943] Shen X et al. Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice. Environ Int. 2019 Jul;128:146-157.  WB ;  Mouse.  222
111 [IF=5.5] Zhong D et al. Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF.(2018)Cell Physiol Biochem.49(3):1163-1179.  IHC&WB ;  Mouse.  222
111 [IF=4.546] Li Mei. et al. Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice. CHIN MED-UK. 2023 Dec;18(1):1-24  IHC ;  Mouse.  222
111 [IF=4.292] Shinkichi Kosaka. et al. Bird’s eye view analysis of in situ cholesterol metabolic pathways in breast cancer patients and its clinicopathological significance in their subtypes. J Steroid Biochem. 2022 Jul;221:106103  IHC ;  Human.  222
111 [IF=4.12] Ma et al. Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. (2017) Sci.Rep. 7:44819  WB ;  Rat.  222
111 [IF=3.97] Ding, Lin, et al. "Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism." Journal of Functional Foods 32 (2017): 90-97.  WB ;  Mouse.  222
111 [IF=3.85] Guo, Hong-li, et al. "Pyrazinamide induced rat cholestatic liver injury through inhibition of FXR regulatory effect on bile acid synthesis and transport."Toxicological Sciences (2016): kfw098.  WB ;  Rat.  222
111 [IF=3.743] Wang N et al. Metabolite profiling of traditional Chinese medicine XIAOPI formula: An integrated strategy based on UPLC-Q-Orbitrap MS combined with network pharmacology analysis. Biomed Pharmacother. 2020 Jan;121:109569.  WB&IHF-F ;  Human&rat.  222
111 [IF=3.241] Zhang L et al. Eicosapentaenoic acid in the form of phospholipid exerts superior anti-atherosclerosis effects than its triglyceride form in ApoE-/-mice. Food & Function. 2019  WB ;  Mouse.  222
111 [IF=3.197] Ding L et al. EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism. Journal of Functional Foods,(2020) 66, 103824.  WB ;  Mouse.  222
111 [IF=3.167] Zhenya Zhai. et al. Policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in C57BL6/mice through AMPK–FXR–TGR5 cross-talk. 2021 Nov 03  IF ;  Mouse.  222
111 [IF=2.97] Wu, Hao, et al. "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." Phytomedicine (2014).  WB ;  
111 [IF=2.96] Gabbi, Chiara, et al. "Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease." Digestive and Liver Disease 44.12 (2012): 1018-1026.  IHC-P ;  Rat.  222
111 [IF=2.86] Nukaya, Daiki, et al. "Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas." Genes to Cells(2015).  Mouse.  222
111 [IF=2.7] Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016).  WB ;  Human.  222
111 [IF=2.19] Zhang, Jin-ming, et al. "Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells." Environmental Toxicology and Pharmacology (2017).  WB ;  Human.  222
111 [IF=2.056] Yu Z et al. Lipidomic Profiling Reveals the Effect of Egg Components on non‐alcoholic Steatosis in HepG2 Cells and its Involved Mechanisms. European Journal of Lipid Science and Technology,2020, 1900451.  WB ;  Human.  222
111 [IF=2.02] Wang, Shuling, et al. "Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats." Lipids in Health and Disease 13.1 (2014): 77.  WB ;  Rat.  222
111 [IF=1.99] Nukaya et al. Preferential gene expression and epigenetic memory of induced pluripotent stem cells derived from mouse pancreas. (2015) Genes.Cells. 20:367-81  IF(ICC) ;  Mouse.  222
研究领域 肿瘤  细胞生物  生长因子和激素  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Guinea Pig,  (predicted: Human, Mouse, Rat, Pig, Rabbit, )
产品应用 ELISA=1:5000-10000 IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 55 kDa
检测分子量
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CYP7A1: 351-400/504 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].

Function:
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue Specificity:
Detected in liver.

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
P22680

Gene ID:
1581

Database links:

Entrez Gene: 1581 Human

Entrez Gene: 13122 Mouse

Entrez Gene: 25428 Rat

Omim: 118455 Human

SwissProt: P22680 Human

SwissProt: Q64505 Mouse

SwissProt: P18125 Rat

Unigene: 1644 Human

Unigene: 57029 Mouse

Unigene: 10737 Rat



产品图片
Paraformaldehyde-fixed, paraffin embedded Human Liver ; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CYP7A1 Polyclonal Antibody, Unconjugated (bs-2399R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with CYP7A1 Polyclonal Antibody, Unconjugated (bs-2399R) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit, SP-0023) and DAB (C-0010) staining.
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