| 产品编号 | bs-2393R |
| 英文名称 | TRPC6 Rabbit pAb |
| 中文名称 | 瞬时受体电位离子通道蛋白6抗体 |
| 别 名 | MTRP6; Short transient receptor potential channel 6; si:rp71-1p14.9; Transient Receptor Potential Cation Channel Subfamily C Member 6; Transient receptor protein 6; TRP 6; TRP-6; TRP6; TRPC 6; TrpC6; TRPC6_HUMAN; TRRP6; bZ1P14.9; FLJ11098; FLJ14863; FSGS2. |
 |
Specific References (3) | bs-2393R has been referenced in 3 publications.
111
[IF=7.419] Zheng-Hao Sun. et al. Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. BIOMED PHARMACOTHER. 2023 May;161:114480 WB ; Human. 222
111
[IF=2.205] Pritesh P Jain. et al. Revisiting the mechanism of hypoxic pulmonary vasoconstriction using
isolated perfused/ventilated mouse lung. 2020 Nov 25 WB ; Mouse. 222
111
[IF=1.851] H Cheng et al. Effect of SKF-96365 on cardiomyocyte hypertrophy induced by angiotensin II. Molecular Medicine Reports 21.2 (2020): 806-814. WB ; Rat. 222
|
| 研究领域 | 细胞生物 免疫学 神经生物学 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=0.2μg/Test （石蜡切片需做抗原修复）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 106 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRPC6: 651-750/931 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq]. Subunit: Interacts with MX1 and RNF24. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Similarity: Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. Contains 4 ANK repeats. SWISS: Q9Y210 Gene ID: 7225 Database links: Entrez Gene: 7225 Human Entrez Gene: 22068 Mouse Omim: 603652 Human SwissProt: Q9Y210 Human SwissProt: Q61143 Mouse Unigene: 159003 Human Unigene: 325086 Mouse Unigene: 105986 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
