| 产品编号 | bs-4189R |
| 英文名称 | SLC10A2 Rabbit pAb |
| 中文名称 | 顶膜钠依赖性胆盐转运体蛋白抗体 |
| 别 名 | ASBT; Apical sodium dependent bile acid transporter; Apical sodium-dependent bile acid transporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na+bile acid cotransporter; Na+dependent ileal bile acid transporter; NTCP2; Sodium/taurocholate cotransporting polypeptide, ileal; solute carrier family 10(sodium/bile acid cotransporter family); Solute carrier family 10 member 2. |
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Specific References (2) | bs-4189R has been referenced in 2 publications.
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[IF=2.97] Wu, Hao, et al. "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." Phytomedicine (2014). WB ;
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[IF=1.69] Ding et al. Bile acid promotes liver regeneration via farnesoid X receptor signaling pathways in rats. (2015) Mol.Med.Re. 11:4431-7 WB ; rat. 222
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| 研究领域 | 肿瘤 免疫学 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human, Mouse, Rat, Dog, Horse, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 38 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASBT: 131-230/348 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
SLC10A2 plays a critical role in reabsorption of bile acids from the the small intestine lumen. Passive flow of sodium ions down their concentration gradient is coupled to bile acid movement, resulting in an increase in the concentration of bile acids in the interior of the cell. This action conserves the body's pool of re-circulating bile acid. SLC10A2 also plays a key role in cholesterol metabolism as cholesterol is the precursor molecule in bile acid synthesis mediated by CYP7A and FXR. Function: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Subunit: Monomer and homodimer. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Primary bile acid malabsorption (PBAM) [MIM:613291]: An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269|PubMed:9109432}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. SWISS: Q12908 Gene ID: 6555 Database links: Entrez Gene: 6555 Human Entrez Gene: 20494 Mouse Omim: 601295 Human SwissProt: Q12908 Human SwissProt: P70172 Mouse Unigene: 194783 Human Unigene: 3500 Mouse Unigene: 85891 Rat
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| 产品图片 |
Sample:
Lane 1: Mouse Kidney Lysates
Lane 2: Rat Kidney Lysates
Primary: Anti-ASBT/SLC10A2 (bs-4189R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kDa
Observed band size: 38kDa
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
