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RabbitAnti-SRD5A2 Rabbit pAb  antibody (bs-6700R)
~~~促销,代码KXJ230206~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-6700R
英文名称 SRD5A2 Rabbit pAb
中文名称 类固醇5α还原酶2抗体
别    名 5 alpha SR2; EC; SR type 2; Steroid 5 alpha reductase 2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; SRD5  
Specific References  (10)     |     bs-6700R has been referenced in 10 publications.
111 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway. J Steroid Biochem. 2021 Nov;214:106001  WB,IHC ;  Bovine.  222
111 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-β/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041  WB ;  Dog.  222
111 [IF=4.24] Tanaka, Sota, et al. "The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma." Molecular and Cellular Endocrinology (2014).  IHC-P ;  Human.  222
111 [IF=3.659] Lu, Shan. et al. An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification. Bmc Complem Altern M. 2022 Dec;22(1):1-20  WB ;  Human.  222
111 [IF=3.415] Kumata H et al. Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.Hepatol Res. 2018 Nov;48(12):989-999.  IHC-P ;  Human.  222
111 [IF=2.984] Junjie Hu. et al. Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. Gene. 2021 Jul;790:145699  WB ;  Sheep.  222
111 [IF=2.923] Hongwei Duan. et al. Melatonin regulates dihydrotestosterone formation via its membrane receptor in the epididymal epithelial cells of sheep. THERIOGENOLOGY. 2022 Dec;:  WB ;  Sheep.  222
111 [IF=2.775] Binghao Bao. et al. Zuogui Wan improves spermatogenesis of GC1-spg cells through modulating AR-related pathways. ANDROLOGIA. 2022 Apr 08  WB ;  Mouse.  222
111 [IF=2.445] Song L et al. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages. Gen Comp Endocrinol. 2019 Aug 12:113245.  WB&IHC-P ;  Yak.  222
111 [IF=1.951] Jisheng Wang. et al. In vitro and in vivo investigation of the therapeutic mechanism of Lycium Chinense and Cuscutae Semen on oligoasthenozoospermia. 2021 Mar 05  WB ;  Rat.  222
研究领域 细胞生物  信号转导  细胞凋亡  细胞周期蛋白  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Horse, )
产品应用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 28 kDa
检测分子量
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SRD5A2: 201-254/254 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Function:
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Subcellular Location:
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).

Tissue Specificity:
Expressed in high levels in the prostate and many other androgen-sensitive tissues.

DISEASE:
Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.

Similarity:
Belongs to the steroid 5-alpha reductase family.

SWISS:
P31213

Gene ID:
6716

Database links:

Entrez Gene: 403715 Dog

Entrez Gene: 6716 Human

Entrez Gene: 94224 Mouse

Entrez Gene: 397048 Pig

Entrez Gene: 64677 Rat

Omim: 607306 Human

SwissProt: P31213 Human

SwissProt: Q3UTZ9 Mouse

SwissProt: Q99N99 Mouse

SwissProt: O18765 Pig

SwissProt: P31214 Rat

Unigene: 458345 Human

Unigene: 38933 Mouse

Unigene: 9938 Rat



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