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RabbitAnti-ApoB Rabbit pAb  antibody (bs-6333R)
~~~促销,代码KXJ230206~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-6333R
英文名称 ApoB Rabbit pAb
中文名称 载脂蛋白B抗体
别    名 Apo B 100; Apo B; Apo B-100; Apo B-48; ApoB 100; ApoB 48; ApoB; APOB protein; APOB_HUMAN; Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B; Apolipoprotein B-48; FLDB.  
Specific References  (1)     |     bs-6333R has been referenced in 1 publications.
111 [IF=11.47] Choi, Won Hoon, et al. "Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation." Nature Communications 7 (2016).  WB ;  Human.  222
研究领域 肿瘤  心血管  细胞生物  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
产品应用 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 241/513 kDa
检测分子量
细胞定位 细胞浆 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Apolipoprotein B: 1501-1700/4563 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.

Function:
Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Subcellular Location:
Secreted.

Post-translational modifications:
Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.

DISEASE:
Defects in APOB are a cause of familialhypobetalipoproteinemia type 1 (FHBL1) [MIM:107730]. A disordercharacterized by highly reduced plasma concentrations of lowdensity lipoproteins, and dietary fat malabsorption. Clinicalpresentation may vary from no symptoms to severe gastrointestinaland neurological dysfunction similar to abetalipoproteinemia.
Defects in APOB are a cause of familial ligand-defectiveapolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantlyinherited disorder of lipoprotein metabolism leading tohypercholesterolemia and increased proneness to coronary arterydisease (CAD). The plasma cholesterol levels are dramaticallyelevated due to impaired clearance of LDL particles by defectiveAPOB/E receptors.
Note=Defects in APOB associated with defects in othergenes (polygenic) can contribute to hypocholesterolemia.

Similarity:
Contains 1 vitellogenin domain.

SWISS:
P04114

Gene ID:
338

Database links:

Entrez Gene: 338 Human

Entrez Gene: 238055 Mouse

Omim: 107730 Human

SwissProt: P04114 Human

SwissProt: E9Q414 Mouse

Unigene: 120759 Human

Unigene: 221239 Mouse



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