| 产品编号 | bs-8306R |
| 英文名称 | Properdin Rabbit pAb |
| 中文名称 | P因子/备解素抗体 |
| 别 名 | BFD; PFC; PFD; PROPERDIN; BCFG; PROP_HUMAN; CFP; Complement factor P; PROP_MOUSE; |
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Specific References (2) | bs-8306R has been referenced in 2 publications.
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[IF=2.96] Chen C et al. Alternative complement pathway is activated in the brains of scrapie‑infected rodents. Med Microbiol Immunol. 2019 Nov 12. IHC-P&IHF ; Mouse&Chinese golden hamsters. 222
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[IF=2.81] Nashine et al. Differential Expression of Complement Markers in Normal and AMD Transmitochondrial Cybrids. (2016) PLoS.On. 11:e0159828 WB ; Human. 222
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| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human, Mouse, Rat, Rabbit, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 48 kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Properdin: 401-469/469 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Involvement in disease:Defects in CFP are the cause of properdin deficiency (PFD). PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). Function: A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Subcellular Location: Secreted DISEASE: Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III). Similarity: Contains 6 TSP type-1 domains. SWISS: P27918 Gene ID: 5199 Database links: Entrez Gene: 5199 Human Entrez Gene: 18636 Mouse Omim: 300383 Human SwissProt: P27918 Human SwissProt: P11680 Mouse Unigene: 53155 Human Unigene: 3064 Mouse Unigene: 204119 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
