| 产品编号 | bs-11463R |
| 英文名称 | Liprin alpha 1 Rabbit pAb |
| 中文名称 | 酪氨酸磷酸酶受体相互作用蛋白Liprin α1抗体 |
| 别 名 | PPFIA1; LAR interacting protein 1; LIP 1; LIP.1; LIP1; LIPRIN; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide(PTPRF) interacting protein(liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; PTPRF interacting protein alpha 1; LIPA1_HUMAN. |
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Specific References (2) | bs-11463R has been referenced in 2 publications.
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[IF=2.314] Che H et al. circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis. Cancer Biother Radiopharm. 2020 Jun 27. WB ; Human. 222
111
[IF=2.314] Hong Cheet al. circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis. Cancer Biother Radiopharm
. 2020 Jun 27. WB ; Human. 222
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| 研究领域 | 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 136 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Liprin alpha 1: 141-190/1202 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is a member of the LARprotein-tyrosine phosphatase-interacting protein (liprin) family.Liprins interact with members of LAR family of transmembraneprotein tyrosine phosphatases, which are known to be important foraxon guidance and mammary gland development. This protein binds tothe intracellular membrane-distal phosphatase domain of tyrosinephosphatase LAR, and appears to localize LAR to cell focaladhesions. This interaction may regulate the disassembly of focaladhesion and thus help orchestrate cell-matrix interactions.Alternatively spliced transcript variants encoding distinctisoforms have been described. [provided by RefSeq, Jul 2008]. Function: This protein is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Subunit: Forms homodimers and heterodimers with liprins-alpha andliprins-beta. Interacts with the second PTPase domain of PTPRD,PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 Subcellular Location: Cytoplasm. Note=Colocalizes with PTPRF atthe ends of focal adhesions most proximal to the cell nucleus. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the liprin family. Liprin-alpha subfamily. Contains 3 SAM (sterile alpha motif) domains. SWISS: Q13136 Gene ID: 8500 Database links: Entrez Gene: 8500 Human Entrez Gene: 233977 Mouse Omim: 611054 Human SwissProt: Q13136 Human Unigene: 530749 Human Unigene: 708791 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
