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RabbitAnti-GSDMD Rabbit pAb  antibody (bs-14287R)
~~~促销，代码KXJ230206~~~
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产品编号 bs-14287R
英文名称 GSDMD Rabbit pAb
中文名称 Gasdermin D蛋白抗体
别    名 DF5L; DFNA5L; FKSG10; GSDMDC1; GSDMD_HUMAN; GSDMD; Gasdermin domain-containing protein 1;  
Specific References  (17)     |     bs-14287R has been referenced in 17 publications.
111 [IF=8.469] Meng, Liping. et al. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Cell Death Dis. 2022 Jan;13(1):1-13  WB,IHC ;  Rat.  222
111 [IF=5.714] Yani He. et al. Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway. INT IMMUNOPHARMACOL. 2023 Jun;119:110192  IHC,IF,WB ;  Human.  222
111 [IF=5.638] Yang F et al. Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy .(2018) Cell Death Dis.9(10):1000.  WB,IHC ;  Mouse.  222
111 [IF=5.055] Meng L et al. Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3. J Mol Cell Cardiol. 2019 Aug 21. pii: S0022-2828(19)30170-1.  WB ;  Rat.  222
111 [IF=4.932] Jindan He. et al. JNK inhibition alleviates delayed neurocognitive recovery after surgery by limiting microglia pyroptosis. Int Immunopharmacol. 2021 Oct;99:107962  WB,IF ;  Mouse.  222
111 [IF=4.858] Kun Hao. et al. Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis. Int J Biol Sci. 2020; 16(16): 3163–3173  WB ;  Rat, Human.  222
111 [IF=4.379] Li, Zhifeng. et al. Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. Sci Rep-Uk. 2022 Feb;12(1):1-13  WB ;  Human.  222
111 [IF=4.057] Yang F et al. Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy. Int J Biol Sci 2019; 15(5):1010-1019.  IF ;  Mouse.  222
111 [IF=3.943] Xiuhong Wang. et al. Protective effect of combination of anakinra and MCC950 against acute lung injury is achieved through suppression of the NF-κB-mediated-MAPK and NLRP3-caspase pathways. Int Immunopharmacol. 2021 Aug;97:107506  WB ;  Mouse.  222
111 [IF=3.886] Zhaochun Liu. et al. Melatonin regulates trophoblast pyroptosis, invasion and migration in preeclampsia by inhibiting HtrA1 transcription through the microRNA-520c-3p/SETD7 axis. 2022 Feb 08  IHC ;  Human.  222
111 [IF=3.61] Yue E et al. Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma.(2018) Phytomedicine.  IF ;  Human.  222
111 [IF=3.418] Chunping Zhu. et al. Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p. 2021 Jun 06  WB ;  Mouse.  222
111 [IF=3.367] Chengcheng Xiao. et al. Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling. Front Physiol. 2020; 11: 906  WB,IF ;  Mouse.  222
111 [IF=3.258] Renhe Wang. et al. Identification of MicroRNA-92a-3p as an Essential Regulator of Tubular Epithelial Cell Pyroptosis by Targeting Nrf1 via HO-1. Front Genet. 2020; 11: 616947  WB,IHC ;  Mouse.  222
111 [IF=3.038] Haixia Gong. et al. Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro. 2021 Feb 03  WB ;  Rat.  222
111 [IF=2.945] Liu, Xin. et al. Dexmedetomidine inhibits endoplasmic reticulum stress to suppress pyroptosis of hypoxia/reoxygenation-induced intestinal epithelial cells via activating the SIRT1 expression. 2021 Sep 29  IF ;  rat.  222
111 [IF=2.705] Yang L et al. High glucose inhibits proliferation and differentiation of osteoblast in alveolar bone by inducing pyroptosis. Biochem Biophys Res Commun. 2019 Nov 25. pii: S0006-291X(19)32206-5.  WB&ICF&IHC-P ;  Mouse.  222
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human,  (predicted: Mouse, Rat, )
产品应用 WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 32/53 kDa
检测分子量 53
细胞定位 细胞浆 细胞膜 细胞外基质 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GSDMD: 31-150/484 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Function:
Belongs to the gasdermin family.

Similarity:
Belongs to the gasdermin family.

SWISS:
P57764

Gene ID:
79792

Database links:

Entrez Gene: 79792 Human

SwissProt: P57764 Human

Unigene: 118983 Human



产品图片
25 ug total protein per lane of various lysates (see on figure) probed with GSDMD polyclonal antibody, unconjugated (bs-14287R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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