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RabbitAnti-HECTD2 Rabbit pAb  antibody (bs-20375R)
~~~促销,代码KXJ230206~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-20375R
英文名称 HECTD2 Rabbit pAb
中文名称 E3连接酶抑制素受体2抗体
别    名 FLJ16050; FLJ37306; HECD2_HUMAN; HECT domain containing 2; HECT domain containing protein 2; HECT domain-containing protein 2; Hectd2; OTTHUMP00000020086; OTTHUMP00000038605; Probable E3 ubiquitin protein ligase HECTD2; Probable E3 ubiquitin-protein ligase HECTD2.  
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 (predicted: Human, Mouse, Rat, )
产品应用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 88 kDa
检测分子量
细胞定位 细胞核 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HECTD2: 701-776/776 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 HECT (Homologous to the E6-AP Carboxyl Terminus) proteins are a large group of E3 ubiquitin-ligases that play a role in the specificity and selectivity of ubiquitylation. The human genome encodes at least 20 different HECT domain proteins, which are grouped into two classes based on their E2 specificity. HECT enzymes also regulate the trafficking of many receptors, transporters, viral proteins and channels. Since HECT proteins are involved in the degradation of vital tumor suppressor molecules, it is theorized that some may contribute to tumorigenesis. HECTD2 (HECT domain-containing protein 2) is a 776 amino acid E3 ubiquitin-ligase that characteristically accepts ubiquitin from an E2 ubquitin-conjugating enzyme and directly transfers the ubiquitin to targeted substrates. Recently, HECTD2 haplotypes have been linked to the susceptibility of acquiring human prion diseases such as Creutzfeldt-Jakob Disease and kuru, which present after a long, clinically silent incubation period that seems to be determined by factors such as genetic background.

Function:
Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity).

Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.

SWISS:
Q5U5R9

Gene ID:
143279

Database links:

Entrez Gene: 143279 Human

Entrez Gene: 226098 Mouse

Entrez Gene: 100172010 Orangutan

Entrez Gene: 309514 Rat

SwissProt: Q5U5R9 Human

SwissProt: Q8CDU6 Mouse

SwissProt: Q5RD78 Orangutan

Unigene: 596096 Human

Unigene: 61107 Mouse

Unigene: 24395 Rat



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