| 产品编号 |
bsk11109 |
| 英文名称 |
Human Human Klotho ELISA Kit |
| 中文名称 |
人klotho跨膜蛋白酶联免疫试剂盒 |
| 别 名 |
KL; entrez:9365 |
| 克 隆 号 |
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| 种 属 |
Human |
| 线性范围 |
39 - 2500 pg/ml |
| 应用范围 |
S/P/CC |
| 检测限 |
40 pg/mL |
| 适用样品基质 |
cell culture supernates, serum, and plasma. |
| 保存条件 |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Klotho is an enzyme that in humans is encoded by the KL gene.This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing, bone loss and alcohol consumption.Transgenic mice that overexpress Klotho live longer than wild-type mice.Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al.The name of the gene comes from Klotho or Clotho, one of the Moirai, or Fates, in Greek mythology.
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