| 产品编号 |
bsk11161 |
| 英文名称 |
Human Human IFN-β ELISA Kit |
| 中文名称 |
人β干扰素酶联免疫试剂盒 |
| 别 名 |
Fibroblast interferon; IFN-Beta; IFF; IFN beta; IFNB 1; IFNB; IFNB1; Interferon beta 1 fibroblast; Beta-IFN; Beta IFN; Interferon beta precursor; MGC96956; Interferon beta; Interferon-beta; IFNB_HUMAN. |
| 克 隆 号 |
|
| 种 属 |
Human |
| 线性范围 |
7.8 - 500 pg/mL |
| 应用范围 |
S/P/CC |
| 检测限 |
4 pg/mL |
| 适用样品基质 |
cell culture supernates, serum, and plasma. |
| 保存条件 |
Store at 4°C for 12 months. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50% amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.
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