| 产品编号 |
IHC0138 |
| 英文名称 |
LRP2 Ready-To-Use IHC Kit |
| 中文名称 |
糖蛋白gp330即用型免疫组化试剂盒 |
| 别 名 |
Calcium sensor protein, DBS, Glycoprotein 330, gp330, Heymann nephritis antigen homolog, Low-density lipoprotein receptor-related protein 2, LRP-2, Lrp2, LRP2_HUMAN |
| 性 状 |
Lyophilized or Liquid |
| 种 属 |
Mouse，Rat |
| 应用范围 |
Immunohistochemistry |
| 适用样品基质 |
FFPE tissue |
| 描述 |
IHC0138 is a ready-to-use IHC kit for staining of LRP2. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data. |
| 保存条件 |
Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
|
|
|
