| 产品编号 | IHC0362H |
| 英文名称 | Human XBP1 Ready-To-Use IHC Kit |
| 中文名称 | 人细胞核转录因子X盒结合蛋白即用型免疫组化试剂盒 |
| 别 名 | D11Ertd39e, HTF, TREB-5, XBP1, X box-binding protein-1, XBP-1, XBP2, Tax responsive element binding protein 5, TREB5, X box binding protein 2, XBP 1, XBP1_HUMAN, X-box-binding protein 1, cytoplasmic form, luminal form, X-box-binding protein 1 in isoform 2 |
| 适用样品基质 | FFPE tissue |
| 保存条件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 产品介绍 |
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. SWISS: P17861 Gene ID: 7494 |
| 产品图片 |
Immunohistochemical analysis of paraffin embedded human pancreas tissue slide using IHC0362H (Human XBP1 Kit).
Immunohistochemical analysis of paraffin embedded human spleen tissue slide using IHC0362H (Human XBP1 Kit).
Immunohistochemical analysis of paraffin embedded human skin tissue slide using IHC0362H (Human XBP1 Kit).
Immunohistochemical analysis of paraffin embedded human testis tissue slide using IHC0362H (Human XBP1 Kit).
Immunohistochemical analysis of paraffin embedded human liver tissue slide using IHC0362H (Human XBP1 Kit).
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
