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产品中心-北京博奥森生物技术有限公司
Recombinant Human MVP Protein, N-His (bs-102006P)
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说明书: 20ug  50ug  100ug
20ug/980.00元
50ug/1880.00元
100ug/2680.00元
大包装/询价
产品编号 bs-102006P
英文名称 Recombinant Human MVP Protein, N-His
中文名称
别    名 LRP; Major vault protein; Lung resistance-related protein; MVP  
克 隆 号
理论分子量 33.29 kDa
性    状 Lyophilized
纯    度 >90% as determined by SDS-PAGE.
缓 冲 液 Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
保存条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

SWISS:
Q14764

Gene ID:
9961

LRP或称MVP(Major vault protein)为肺耐药相关蛋白。其耐药机制与该蛋白质参与细胞核-浆的运输有关。 他在正常细胞有广泛分布,对多种药物耐药的癌细胞呈过度表达,亦属多药耐药(MDR)中的一种表型,可表达于许多肿瘤组织中,阳性者预示对化疗不敏感,主要用于各种恶性肿瘤的研究。
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