| 产品编号 | bs-1505R-FITC |
| 英文名称 | Anti-Vasohibin 1/FITC |
| 中文名称 | FITC标记的血管抑制蛋白1抗体 |
| 别 名 | Vasohibin; KIAA1036; VASH; VASH; VASH1; VASH1_HUMAN; Vasohibin1; Vasohibin-1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, ) |
| 产品应用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human VASH1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 |
background: VASH1 is a angiogenesis inhibitor. It inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. It does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis and acts in an autocrine manner. VASH1 also inhibits artery neointimal formation and macrophage infiltration and exhibits heparin-binding activity. There are two named isoforms. Function: Angiogenesis inhibitor. Inhibits migration,proliferation and network formation by endothelial cells as well asangiogenesis. This inhibitory effect is selective to endothelialcells as it does not affect the migration of smooth muscle cells orfibroblasts. Does not affect the proliferation of cancer cells invitro, but inhibits tumor growth and tumor angiogenesis. Acts in anautocrine manner. Inhibits artery neointimal formation andmacrophage infiltration. Exhibits heparin-binding activity. Subcellular Location: Secreted. Tissue Specificity: Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. Post-translational modifications: 2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa)may be processed by proteolytic cleavage. The largest form (42 kDa)seems to be secreted and the other major form (63 kDa) seems toaccumulate within the cells or pericellular milieu. Polypeptideconsisting of Met-77 to Arg-318 may correspond to the 27 kDa formand that consisting of Met-77 to Val-365 may correspond to the 36kDa form. Similarity: Belongs to the vasohibin family. Database links: Entrez Gene: 22846 Human Entrez Gene: 238328 Mouse Omim: 609011 Human SwissProt: Q7L8A9 Human SwissProt: Q8C1W1 Mouse Unigene: 525479 Human Unigene: 216101 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. VASH1是一个内皮组织衍生的可被血管内皮生长因子诱导的分泌性蛋白质,它是目前为止发现的唯一以负反馈为作用机制调节血管新生的因子。它的发现证实在血管新生的过程中也存在经典的自身调节控制机制—负反馈调节机制的存在。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
