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Rabbit Anti-NCX3/BF555 Conjugated antibody (bs-2057R-BF555)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-2057R-BF555
英文名称 Anti-NCX3/BF555
中文名称 BF555标记的钠钙交换蛋白3抗体
别    名 AW742262; MGC90626; Na(+)/Ca(2+)-exchange protein 3; Na+/Ca2+ exchange protein 3; Na+/Ca2+ exchanger 3; NAC3_HUMAN; NCX3; SCL8A3; Sodium calcium exchanger form 3; Sodium/calcium exchanger 3; Sodium/calcium exchanger SLC8A3; Solute carrier family 8 sodium calcium exchanger member 3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NCX3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SLC8A3 is a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner.

Function:
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.

Similarity:
Belongs to the sodium/potassium/calcium exchangerv family. SLC8 subfamily.
Contains 2 Calx-beta domains.

Database links:

Entrez Gene: 6547 Human

Entrez Gene: 110893 Mouse

Entrez Gene: 140448 Rat

Omim: 607991 Human

SwissProt: P57103 Human

SwissProt: P70549 Rat

Unigene: 337696 Human

Unigene: 443748 Mouse

Unigene: 67030 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

钠钙交换蛋白又称钠钙交换体,有三种同分异构体,即NCX1、NCX2和NCX3。3型Na-Ca交换蛋白-NCX3, 主要在脑组织表达,分布与胞浆及胞膜。
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