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Rabbit Anti-SLC40A1/PE-Cy7 Conjugated antibody (bs-4906R-PE-Cy7)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-4906R-PE-Cy7
英文名称 Anti-SLC40A1/PE-Cy7
中文名称 PE-Cy7标记的细胞膜铁转运蛋白FP1抗体
别    名 Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  转录调节因子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Dog, Pig, Rabbit, )
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 63kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC40A1/FPN1 (365-405aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin.

Function:
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subunit:
Belongs to the S1LC40A transporter family.

Subcellular Location:
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.

Tissue Specificity:
Expressed in placenta, intestine, muscle and spleen.

DISEASE:
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.

Similarity:
Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Database links:

Entrez Gene: 30061 Human

Entrez Gene: 53945 Mouse

Entrez Gene: 170840 Rat

Omim: 604653 Human

SwissProt: Q9NP59 Human

SwissProt: Q9JHI9 Mouse

SwissProt: Q923U9 Rat

Unigene: 643005 Human

Unigene: 28756 Mouse

Unigene: 15324 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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