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Rabbit Anti-ATG9B/BF350 Conjugated antibody (bs-4011R-BF350)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-4011R-BF350
英文名称 Anti-ATG9B/BF350
中文名称 BF350标记的自噬相关蛋白9B抗体
别    名 APG9 like 2; APG9-like 2; APG9L2; Apgdc2; ATG9 autophagy related 9 homolog B; Atg9b; Autophagy related protein 9B; Autophagy-related protein 9B; eONE; Gm574; Nitric oxide synthase 3 overlapping antisense gene protein; Nitric oxide synthase 3-overlapping antisense gene protein; NOS3AS; Protein sONE; SONE; Apg912.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  细胞凋亡  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,  (predicted: Human, Dog, Pig, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 94kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ATG9B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
This gene functions in the regulation of autophagy, a lysosomal degradation pathway. This gene also functions as an antisense transcript in the posttranscriptional regulation of the endothelial nitric oxide synthase 3 gene, which has 3' overlap with this gene on the opposite strand. Mutations in this gene and disruption of the autophagy process have been associated with multiple cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Function:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.

Subcellular Location:
Cytoplasmic vesicle ?autophagosome membrane; Multi-pass membrane protein. Note: Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1 and ATG13.

Tissue Specificity:
Highly expressed in placenta (trophoblast cells) and pituitary gland. Not expressed in vascular endothelial.

Similarity:
Belongs to the ATG9 family.

Database links:

Entrez Gene: 285973 Human

Entrez Gene: 213948 Mouse

Entrez Gene: 499973 Rat

Omim: 612205 Human

SwissProt: Q674R7 Human

SwissProt: Q6EBV9 Mouse

Unigene: 707300 Human

Unigene: 716846 Human

Unigene: 332252 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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