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Rabbit Anti-Triosephosphate isomerase/Cy5 Conjugated antibody (bs-4042R-Cy5)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-4042R-Cy5
英文名称 Anti-Triosephosphate isomerase/Cy5
中文名称 Cy5标记的磷酸丙糖异构酶抗体
别    名 TIM; TPI 1; TPI; TPI1; Triose phosphate isomerase 1; Triose phosphate isomerase; Triosephosphate isomerase 1; Triosephosphate isomerase; MGC88108; TPIS_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Triosephosphate isomerase
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Subunit:
Homodimer.

Post-translational modifications:
The initiator methionine for isoform 2 is removed.

DISEASE:
Triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]: Autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the triosephosphate isomerase family.

Database links:

UniProtKB/Swiss-Prot: P60174.3

Entrez Gene: 281543 Cow

Entrez Gene: 7167 Human

Entrez Gene: 21991 Mouse

Entrez Gene: 24849 Rat

Omim: 190450 Human

SwissProt: Q5E956 Cow

SwissProt: P54714 Dog

SwissProt: P60174 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    磷酸丙糖异构酶(Triose-phosphate isomerase,通常简称为TPI或TIM)是一种能够催化丙糖磷酸异构体在二羟丙酮磷酸和D型甘油醛-3-磷酸之间转换。
    磷酸丙糖异构酶在糖酵解中具有重要作用,对于有效的能量生成是必不可少的。磷酸丙糖异构酶被发现存在于几乎所有的生物体,包括哺乳动物、昆虫、真菌、植物和大多数细菌中。
    如果人体缺乏磷酸丙糖异构酶,会导致严重的神经系统紊乱,该病症被称为磷酸丙糖异构酶缺乏症。
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