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Rabbit Anti-phospho-SIRT6 (Ser338)/PE-Cy5 Conjugated antibody (bs-5634R-PE-Cy5)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-5634R-PE-Cy5
英文名称 Anti-phospho-SIRT6 (Ser338)/PE-Cy5
中文名称 PE-Cy5标记的磷酸化沉默调节相关蛋白6抗体
别    名 SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); Sirtuin 6; Sirtuin type 6; Sirtuin6.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 肿瘤  心血管  免疫学  染色质和核信号  信号转导  细胞凋亡  新陈代谢  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Subunit:
Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.

Subcellular Location:
Nucleus, nucleoplasm.

Similarity:
Belongs to the sirtuin family. Class IV subfamily.
Contains 1 deacetylase sirtuin-type domain.

Database links:

Entrez Gene: 51548 Human

Entrez Gene: 50721 Mouse

Entrez Gene: 299638 Rat

Omim: 606211 Human

SwissProt: Q8N6T7 Human

SwissProt: P59941 Mouse

Unigene: 423756 Human

Unigene: 131825 Mouse

Unigene: 25643 Mouse

Unigene: 8108 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SIRT6是一种酶,能够从组蛋白的一个特定位点上移走称之为乙酰基组的化学物质。组蛋白对调控基因表达非常重要,而从组蛋白中移除乙酰基组就会“关闭”某些基因表达。 SIRT6蛋白与NF-kappaB(NF-kB)一同,可以调节凋亡、炎症和新陈代谢相关基因的作用。当减少SIRT6时,NF-kappaB变得过度活跃,开启同衰老相关的基因。
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