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Rabbit Anti-GAD65 + GAD67/Cy5 Conjugated antibody (bs-13263R-Cy5)
~~~促销,代码KXJ230206-6~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
技术支持:techsupport@bioss.com.cn
说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-13263R-Cy5
英文名称 Anti-GAD65 + GAD67/Cy5
中文名称 Cy5标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体
别    名 65 kDa glutamic acid decarboxylase; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65;GAD 65, GAD2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2; Glutamate Decarboxylase 65; Glutamate decarboxylase 65 kDa isoform; Glutamic Acid Decarboxylase 2; Glutamic Acid Decarboxylase 65; DCE1_HUMAN; DCE2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65+67kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GAD65 + GAD67
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.

Function:
Catalyzes the production of GABA.

Subcellular Location:
Cytoplasm; cytosol. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

Similarity:
Belongs to the group II decarboxylase family.

Database links:

Entrez Gene: 2572 Human

Entrez Gene: 14417 Mouse

Entrez Gene: 24380 Rat

Omim: 138275 Human

SwissProt: Q05329 Human

SwissProt: Q5VZ29 Human

SwissProt: Q5VZ30 Human

SwissProt: P48320 Mouse

SwissProt: Q548L4 Mouse

SwissProt: Q05683 Rat

Unigene: 231829 Human

Unigene: 4784 Mouse

Unigene: 29951 Rat


Entrez Gene: 2571 Human

Entrez Gene: 14415 Mouse

Entrez Gene: 24379 Rat

Omim: 605363 Human

SwissProt: Q99259 Human

SwissProt: P48318 Mouse

SwissProt: P18088 Rat

Unigene: 420036 Human

Unigene: 272120 Mouse

Unigene: 91245 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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