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Rabbit Anti-FAM175B/Gold Conjugated antibody (bs-14763R-Gold)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-14763R-Gold
英文名称 Anti-FAM175B/Gold
中文名称 胶体金标记的FAM175B蛋白抗体
别    名 AA589499; Abraxas brother 1; ABRO 1; ABRO; F175B_HUMAN; ABRO1; AI853413; C430003P19Rik; Em:AC068896.4; Family with sequence similarity 175, member B; FLJ22338; hypothetical protein LOC23172; KIAA0157; OTTHUMP00000020697; RGD1308918.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FAM175B
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
FAM175B (ABRO1) is a 415 amino acid protein, sharing 39% identity to ABRA1 in the N terminal two thirds of the protein (amino acids 1 to 260), including a coiled-coil domain and a region called the ABR domain. However, ABRO1 lacks the phosphorylated ser-X-X-phe motif of ABRA1 and, unlike ABRA1, does not bind to BRCA1.

Function:
Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex.

Subunit:
Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Does not interact with BRCA1. Binds polyubiquitin.

Similarity:
Belongs to the FAM175 family. Abro1 subfamily.

Database links:

Entrez Gene: 23172 Human

Entrez Gene: 109359 Mouse

Entrez Gene: 293570 Rat

Omim: 611144 Human

SwissProt: Q15018 Human

SwissProt: Q3TCJ1 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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