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Rabbit Anti-LUZP4/CT28/Gold Conjugated antibody (bs-18447R-Gold)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包装/询价
产品编号 bs-18447R-Gold
英文名称 Anti-LUZP4/CT28/Gold
中文名称 胶体金标记的亮氨酸拉链蛋白4抗体
别    名 Cancer/testis antigen 28; CT 8; CT-28; CT28; ENSMUSG00000072927; HOM TES 85; HOM TES 85 tumor antigen; Leucine zipper protein 4; LUZP4; LUZP4_HUMAN; OTTHUMP00000023875; RP1-237H22.1; RP23-463M4.2; Tumor antigen HOM-TES-85.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul(10nm  15nm  35nm
研究领域 肿瘤  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human, )
产品应用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
性    状 Lyophilized or Liquid
浓    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LUZP4/CT28
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存条件 Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
产品介绍 background:
This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].]

Function:
Export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Binds NXF1, enhances its RNA-binding activity and is required for its localization to the nuclear rim. Associates with the TREX complex via its interaction with the TREX components THOC1, THOC5 and DDX39B/UAP56. Capable of complementing knockdown of ALYREF/THOC4 and partially complementing a double ALYREF/UIF knockdown in vivo. Required for the growth of the melanoma cell line MeWo (PubMed:25662211).

Subunit:
Interacts NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.

Subcellular Location:
Nucleus. Cytoplasm. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division.

Tissue Specificity:
Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.

Database links:

Entrez Gene: 51213 Human

Omim: 300616 Human

SwissProt: Q9P127 Human

Unigene: 242183 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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