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Rabbit Anti-MLK2/MAP3K10/PE-Cy7 Conjugated antibody (bs-18953R-PE-Cy7)
~~~促销,代码KXJ230206-6~~~
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说 明 书: 100ul  
100ul/2980.00元
大包装/询价
产品编号 bs-18953R-PE-Cy7
英文名称 Anti-MLK2/MAP3K10/PE-Cy7
中文名称 PE-Cy7标记的丝裂原活化蛋白激酶激酶激酶10抗体
别    名 M3K10_HUMAN; MAP3K 10; MAP3K10; MEKK10; Mitogen activated protein kinase kinase kinase 10; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; MKN28 derived nonreceptor type serine/threonine kinase; MKN28 kinase; MLK 2; MST; Protein kinase MST  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  细胞凋亡  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,  (predicted: Human, Rat, Pig, Cow, Rabbit, Xenopus laevis)
产品应用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 103kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MLK2/MAP3K10
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

Function:
Activates the JUN N-terminal pathway.

Tissue Specificity:
Expressed in brain and skeletal muscle.

Post-translational modifications:
Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.

Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 4294 Human

Entrez Gene: 269881 Mouse

Entrez Gene: 308463 Rat

Entrez Gene: 398612 Xenopus laevis

Omim: 600137 Human

SwissProt: Q02779 Human

SwissProt: Q66L42 Mouse

SwissProt: Q7T2V3 Xenopus laevis

Unigene: 466743 Human

Unigene: 389883 Mouse

Unigene: 26500 Xenopus laevis



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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